亚博手机版

创新创业Innovation
创新创业
当前位置: 亚博手机版  > 创新创业  > 正文
蛋白质科学团队在线粒体分选转运机制研究中取得突破
发布时间: 2019-09-14

9yue8ri,yaboshoujibanzuowuyichuangailiangguojiazhongdianshiyanshi、shengmingkexuejishuxueyuandanbaizhikexueyanjiutuanduiyuqinghuadaxueyanchuangyeyanjiuyuanhezuo,zaizhongkeyuanzhuguandecell researchzazhizaixianfabiaotiwei“cryo-em structure of the human mitochondrial translocase tim22 complex”(《renxianlitizhuanweimeitim22fuhewudelengdongdianjingjiegou》)deyanjiulunwen,zheishiguojishangshoucibaodaoyouguanxianlitineimozhuanweimeitim22fuhewudegaofenbianlvlengdongdianjingjiegou。

xianlitizaixibaoshengminghuodongzhongzhixingbaokuonengliangdaixie、xibaochengxuxingsiwangdengzhongyaozuoyong。zaixianlitijinhuaguochengzhong,qiyichuanxitongjingguozhongpai,daduoshuxianlitidezishenjiyinbeizhuanyizhixibaohehuozhediushi。yinci,xianlitizhong99%dedanbaixuyaozaixibaozhizhonghetangtishanghechengbingjingquedizhuanyundaotedingxianlitiyajiegouquyucainengfahuiqigongneng。erxianlitidanbaizhuanyunyouzhuyaohanyouliuzhongdanbaizhuanyunfuhewudexianlitidanbaizhizhuanyunxitongfuze,baokuoxianlitiwaimozhuanweimei(tom)、xianlitineimoqiandaoxuliezhuanweimei(tim23)、xianlitineimozaitidanbaizhuanweimei(tim22)、xianlitiwaimofenxuanhezhuangpeijiqi(sam)、xianlitizhuanyunfuhewu(mim)hexianlitimojianxizhuanyunyuzhuangpeijiqi(mia)。xianlitizhuanyunxitongquexianhuogongnengwenluan,huidaozhiduozhongfuzaderenleijibing,liruaizheng、shenjingtuixingxingjibinghejirouzuzhixiangguanjibing。

zaitidanbaishihanyouliucikuamoluoxuandemodanbaideyileidingweiyuxianlitineimo,tatongguocujintedingdediwukuosantongguoxianlitineimohuozheliyongmodianshizhuanyundaixiewuzhi,laiwanchengdaixiewuzhizhuanyunjinruhuozhezhuanchuxianlitijizhi。zaitidanbaishengwufashengyoutomhetim22fuhewuwancheng。tim22fuhewufuzezaitidanbaizhuanyunhecharudaoxianlitineimo。renyuantim22fuhewubaohanzhishao6gezufen: tim22、tim29、tim9、tim10a、tim10b and agk。jinguanzaitim22fuhewudegongnenghejibingfashengyanjiuzhongqudelehendajinzhan,danshitim22fuhewudejiegoutezhenghezaitidanbaidezhuanyunjizhiyiranbuqingchu。

亚博手机版zaigaiyanjiuzhong,yaboshoujibandanbaizhikexueyanjiutuanduichenggongjiangtim22fuhewu6geyajizaiburudongwuxibaobiaodatixizhonggongbiaoda,tongguolengdongdianjingdefangfajinxingshujushoujihechuli,jiexiletim22fuhewudejinyuanzifenbianlvjiegou。jieguobiaoming,zaitim22fuhewujiegouzhong,hanyou1fenzitim22、tim29、agkdanbai;hanyou2gefenzibanlvliujutifuhewutim9/10a(3:3)hetim9/10a/10b(2:3:1)。

人源线粒体内膜转位酶TIM22复合物冷冻电镜结构示意图

人源线粒体内膜转位酶TIM22复合物冷冻电镜结构示意图

tim29shiyigedancikuamodanbai,tongguoqinduanluoxuanlaiwendingtim22danbaijiegou,tongshitongguoqicduanmojianxijiegouyuyuagkhe2gefenzibanlvliujutifuhewuxianghuzuoyonglaiweichitim22fuhewudewanzhengxing。tim9/10afuhewujieshoutongguoxianlitiwaimozhuanweimeitomfuhewutongdaodezaitidanbaiqianti,bingchuandijitim9/10a/10bfuhewu,zuihouchengdijitim22danbai。tim22danbaibaohan4gekuamoluoxuan,xingchengyigekaikouchaoxiangzhishuangcengdekongqiang,tuicegaikongqiangcanyuzaitidanbaidechamohehengxiangfenxuandaoxianlitineimoguocheng。gaiyanjiujieshiletim22fuhewudezishenzhuangpeihexiangxidejiegouxinxi,weijinyibulijieheyanjiuzaitidanbaitongguotim22fuhewucharudaoxianlitineimodefenzijizhitigongjiegoujichu,yeweixianlitizhuanyunxitongxiangguanjibingtigongqianzaideyaowubadian。

shengkeyuanboshishengqiliangbo、wangqiangheguanzeyuanweigailunwengongtongdiyizuozhe,yinpingjiaoshouheyanchuangyeyanjiuyuanweigongtongtongxunzuozhe。qianqilengdongyangpinzhibeiheyangpinshaixuanzhuyaozaiyaboshoujibandianjingpingtaiwancheng,lengdongdianjingshujushoujizaizhejiangdaxuelengdongdianjingzhongxinwancheng。gaiyanjiushoudaolekejibujijin、guojiazirankexuejijin、xiaozizhuchuangxinjijindezizhu。

---友情链接---

版权所有:亚博手机版

dizhi: hubeishengwuhanshihongshanqushizishanjie1haoyaboshoujiban    youxiang: yjs@mail.31thestore.com    dianhua:     youbian: 430070   

亚博手机版 电竞竞猜app_最佳电竞竞猜平台|亚博手机版 yabo88_yabo88官网|信誉平台 炸金花app|官方平台 ag真人彩票_ag真人登录|官方平台 足球大赢家_足球比分_即时比分|官网