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微生物免疫团队鉴定新型CRISPR信号分子降解酶
发布时间: 2019-09-18

jinri,cell reportszazhizaixianfabiaoleyaboshoujibannongyeweishengwuguojiazhongdianshiyanshi、shengmingkexuejishuxueyuanweishengwumianyituanduijiexicrispr-casxitongmianyihuoxingdiaokongdezuixinyanjiuchengguo。chengguolunwenyi“a membrane-associated dhh-dhha1 nuclease degrades type iii crispr second messenger”weiti,shoucijiandingjinshuyilaide、xibaomoguanliande、jiangjieiiixing crispr-casxitongdierxinshidehesuanmei,yanjiubiaoming,gaimeikenengcanyudiaokongiiixingxitongdemianyihuoxing,bimianchixudemianyixiangyingduixibaozaochengsunhai。

亚博手机版crispr-casxitongshiyuanheshengwuyonglaidiyuwailaiyichuanyuanjianruqindehuodexingmianyixitong。qizhong,iiixing crispr-casxitongjuyouduozhongmianyihuoxing,qixiaoyingfuhewunenggou: (1) qiegecrrnapipeidebabiaorna;(2) zaijiehebabiaornashi,qiegezhuanlupaozhouweidessdna;(3) zaijiehebabiaornashi,hechengdierxinshi——huanguajuxiangansuan(coa);coanenggoujiehexiayouxiaoyingwucsm6/csx1,bingjihuohouzhegaoxiaoqiegefeiteyixingssrna。cishibujinruqinhesuanyuanjiandezhuanlubenhuishoudaojiangjie,suzhuzhuanlubenyehuibeiqiege,congeryinqixibaoxiumian。iiixingxitongsuojihuodehetanghesuanmeihuoxingxuyaoshoudaoyangedekongzhi,fouzehuidaozhifeiyuqidexibaoduxingshenzhixibaosiwang。

2018nian,yingguom.f. whiteketizufaxianyizhonghanyoucarfjiegouyu、beichengweihuanhesuanmeidedanbaizhinenggouyibuyilaijinshulizidefangshiqiegecoa,bingkenengcanyudiaokongiiixingxitongdemianyihuoxing。raner,huanhesuanmeidehuoxingbuzuyijiangjiegaonongdudecoa,eriiixingxitongdexiaoyingfuhewuqiaqiajuyougaoxiaodecoahechengnengli。zheimaodunzhichuanshicunzaiweizhiyinsucanyuiiixingxitongmianyihuoxingdediaokong。

亚博手机版2020nian9yue15ri,yaboshoujibanhanwenyuanketizuzaicell reportszazhifabiaolebiaotiwei“a membrane-associated dhh-dhha1 nuclease degrades type iii crispr second messenger”deyanjiuchengguo。gaiyanjiufaxianlejiangjiecoadexinxinghesuanmei。gaimeikenengcanyudiaokongiiixingxitongdemianyihuoxing,bimianchixudemianyixiangyingduixibaozaochengsunhai。

zuozheshouxiancongbingdaoliuhuayejundexibaotiquwuzhongjiandingchulejinshuliziyilaide、xibaomoguanliandecoajiangjiehuoxing,bingfaxianzaigaocoanongduxia,jinshuyilaidecoajiangjiehuoxingxianzhutigaoleqingchucoadexiaolv。suihou,zuozhefenlidedaolejinshuliziyilaidedhh-dhha1jiazuhesuanmei(mad),bingduiqijinxingleyixilietinei、tiwaiyanjiu。jieguobiaomingmadjuyousangetedian: (1)juyoujigaodecoajiangjienengli;(2)jiehezaixibaomoshang;(3)juyoufeiteyixingdednahernajiangjiehuoxing。

图1. 膜关联DHH-DHHA1核酸酶(MAD)参与调控III型系统免疫活性的工作模型

图1. 膜关联DHH-DHHA1核酸酶(MAD)参与调控III型系统免疫活性的工作模型

genjuzheixietedian,zuozhetichulemaddegongzuomoxing。bingduruqinyinfaiiixingcrispr-casxitongdemianyixiangying,tongguohechengcoajifacsx1dehesuanmeihuoxing。zaicoashuipingjiaodishi,coazhuyaoyouhuanhesuanmeijiangjie,ermaddemoguanliandetedianhuixianzhiqiduixinshengcoadejiangjie,congerbimianguozaoguanbimianyixiangying;dangcoadenongduchaoguohuanhesuanmeidejiangjienenglishi,kuosandaoxibaomozhouweidecoahuibeimadkuaisujiangjie,congerbimianmianyixiangyingchixutaizhangshijianduixibaozaochengsunhai。zheixiefaxianbiaoming“congming”deweishengwunenggoufuza、jingzhundidiaokongmianyixiangying,congeryingduibutongbingduruqindeqingkuang,zaiyubingdudezhanzhengzhongcunhuo。

shengmingkexuejishuxueyuanshuoshiyanjiushengzhaoruiliangheyangyangweigongtongdiyizuozhe,hanwenyuanjiaoshouweigaiyanjiudetongxunzuozhe。liangyunxiangjiaoshouheshandongdaxueshequnxinjiaoshoucanyubufengongzuo。gaiyanjiudedaolexiaoqidongjingfei、guojiazirankexuejijin、xiaozizhuchuangxinjijindezizhu。

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