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左波教授团队在肌肉生长发育表观调控研究上取得新进展
发布时间: 2019-10-06

亚博手机版jinri,guojixueshuqikan《eyezhi、jiroujianshaozhenghejirouzazhi》(journal of cachexia, sarcopenia and muscle)zaixianfabiaoleyaboshoujibandongkedongyixueyuanzuobojiaoshoutuanduitiwei“lncmgpf is a novel positive regulator of muscle growth and regeneration”dezuixinyanjiuchengguo。benyanjiuzaixiaoshu、zhuherenzhongjiandingleyigexindecujinjiroushengzhanglncrna—lncmgpf,gailncrnazhuyaotongguozengqiangrenkangyuanr(hur)jiedaodejiyuanxingdiaojiejiyinmrnawendingxingyijizuoweimir-135a-5pfenzihaimiancujinjiroushengzhanghezaisheng。

gugejishirentihedongwujitiyundongxitongzuchengbufen,gugejishengzhangsuduhezhongliangyeshinongyedongwushengchanzhongzhongyaodejingjixingzhuang。gugejishengzhangfayushiyigefuzadeguocheng,shoudaoneizaiyichuan、biaoguanyichuanhegezhongxinhaoyinzidengdediaokong。zhanglianfeibianmarna(lncrnas)shiyileizhangduchaoguo200nt、bunengbianmadanbaihuozhinengbianmaduantaidernafenzi,canyudiaokongleduozhongshengwuxueguocheng。lncrnasjiedaodebiaoguandiaokongzaijiroushengzhangfayuguochengzhongqidaolezhongyaodezuoyong,muqianzaijirouzhongyijingjiandingchuleshangwantiaolncrnas,dandabufengongnengshangbuqingchu。

gaiyanjiutuanduiliyongqianqijianlidejixibaolncrnabiaodashujuku,tongguoshengwuxinxixuefenxijiandingle19geyushengjijuedingyinzimyodjiyinbiaodachenggaoduxiangguandelncrnas,zaicijichushangshaixuanleyigezaijirouzhonggaobiaodaqieshoumyodzhengdiaokongdelncrna,bingmingmingweilncmgpf(lncrna muscle growth promoting factor)。gailncrnazairen、zhuhexiaoshujiyinzuweizhiyijiguanjiangongnengquxuliejuyoubaoshouxing。tongguoxibaoshuiping、jiyinqiaochumoxing、jirouchaobiaodadenggongnengyanzheng,tuanduifaxianlexiaoshu、zhuherenlncmgpfjuyoucujinjixibaofenhuahejiroushengzhangfayudegongneng。lncmgpfjiyinqiaochudaozhixiaoshushengzhangsudu、jirouzhonglianghejixianweimianjixianzhujiangdi,jirousunshangxiufuguochengyanchi,erzaijirouzhongchaobiaodalncmgpfkexianzhucujinjiroushengzhang、zengjiajixianweimianjihejirouliang。zaizuoyongjizhishang,lncmgpfzhuyaotongguoliangfangmiandiaokongjishengcheng,yishizuoweimir-135a-5pfenzihaimian,zengjiajixibaozengqiangyinzi2c(mef2c)biaoda;ershitongguodiaokonghurdanbailiejiecujinhuryouxibaohedaoxibaozhideqianyi,zengqianghurjiedaodejiyuanxingdiaojiejiyinmyog、myoddengmrnadewendingxing,jinertigaojixibaofenhuanengli。gaiyanjiujieguoweijiroushengzhangfayuyanjiutigonglexindediaojieyinzihebiaoguandiaokongjizhi,zaidongwujiroushengzhangxingzhuangdiaokongyujirouzaishengdenglingyujuyouqianzaideyingyongjiazhi。

亚博手机版jinnianlai,gaiyanjiutuanduizaijiroushengzhangfayulncrnasbiaoguandiaokongfangmianqudelejiaoxitongdeyanjiuchengguo,xianhoujiandingleak143003(sci rep,2017)、syisl(pnas,2018)、neat1(cell death dis,2019)dengduogejishengchengxiangguandelncrnas。

亚博手机版yaboshoujibandongkedongyixueyuanboshiyanjiushenglvweiheboshihoujinjianjunweigailunwendegongtongdiyizuozhe,zuobojiaoshouweilunwentongxunzuozhe。gaiyanjiudedaoleguojiazhuanjiyinzhongdazhuanxiang、guojiazirankexuejijin、zhongguoboshihoukexuejijindengzizhu。

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